Even though the matrix is not rigit, it may occasionaly remains intact and excreted in the feces.(Similar to carbamazepin, nifedipine ext rel and others, actually, we need to consult patients about seeing empty matrix in the stool - don't worry if you see ... I have come across with a real case where the patient found Metformin 1000mg XR in the stools with out getting dissolved completely. Also find out if he suffering from any GI disease, cos the tablet needs gastric secretions for the initial phase of dissolution and normal GI peristalsis for the tablet to be broken down later and excreted in feces as a soft mass. If drug brand names have XR, CR, SR, DR like suffix (special ends with "R"), then that drug cannot be crushed... This universal rule does not apply for these categories of drug (buccal drugs). About undissolved pieces of tablets in the stool: since it is extended release tabs, they made a polymer matrix with the drug incorporated into it. Then drug will slowly released from the matrix (based on p H dif). He should be advised to drink water with the med , to aid in dissolution. I believe that extended release formulations can't be crushed, unless manufacturer specifies it. In the case above, we need to find out how he is administering his medication and what is his other disease states.. I don't remember one other drug but on naplex digest they have asked one question on that drug. The whole point of the release technology is lost ,except in special cases like metoprolol succinate where it can be broken along the split line to take half the dose . etc.) If it is dissolution; usually related with moisture not p H. Extended release have to have different release phase (e.g. Metformin have immediate release component and then matrix based extended release component. My boyfriend Sam belongs to the kind of men that start losing their hair pretty early. I love him and this doesn't really matter for me whether curly or bald. And moreover I know how difficult it is for a man to get back his natural hair as my father throughout his lifetime was struggling against baldness and actually he flopped. That's why I told Sam that hair meant nothing and I loved him the way he was, but he was in despair, he didn't want to give up the struggle. Then I bought Propecia for him, just to clear my conscience. Can you imagine my astonishment when in a month I saw that his hair grows again! Now Sam continues taking Propecia and is not going to stop. If only my poor daddy knew about such an amazing medicine! Buy ventolin in the forums Zoloft overdose side effects Buy cytotec online fast delivery Lasix tablet Can Metformin be crushed to making taking easier? I'm taking the generic pills and they taste absolutely awful. I always get a little of the bitter after-taste at Jan 16, 2015. Metformin should be taken at the same times each day. The extended-release tablets should not be chewed, split, or crushed. Swallow. 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Can I crush tablets Diabetes Forum • The Global. Diabetes can be hard on a marriage. But here are six ways that couples can cope with it I believe that extended release formulations can't be crushed, unless manufacturer specifies it. About undissolved pieces of tablets in the stool since it is extended release tabs, they made a polymer matrix with the drug incorporated into it. Lactic acidosis can occur due to metformin accumulation. hydrochoride extended-release tabets must be swalowed whoe and never spit, crushed or chewed.