Azithromycin dihydrate

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    Azithromycin dihydrate


    It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. It is structurally related to erythromycin subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at the 9a position on the aglycone ring, which allows for the prevention of its metabolism. (2R,3S,4R,5R,8R,10R,11R,12S,13S,14S)-11-((2S,3R,4S,6R)- 4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-((2S,4R,5S)-5-hydroxy-4-methoxy-4-methyltetrahydro-2H-pyran-2-yloxy)-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-on Azithromycin ist eine organische chemische Verbindung aus der Gruppe der Glycoside, der als antibiotisch wirkender Arzneistoff der Gruppe der Makrolid-Antibiotika eingesetzt wird. Mittlerweile klassifiziert man den Wirkstoff auch als ersten Vertreter der Azalide. Eine Forschergruppe des pharmazeutischen Unternehmens Pliva in Zagreb im damaligen Jugoslawien um Slobodan Dokić, Gabrijela Kobrehel, Gorjana Radobolja-Lazarevski und Zrinka Tamburašev entdeckte Azithromycin 1979/1980. Es wurde 1981 patentiert und war ab 1988 als Sumamed im Bereich des sozialistischen Mittel-Osteuropas erhältlich. Bereits 1986 wurde mit Pfizer ein Vertrag geschlossen, der diesem 1991 die Markteinführung in Westeuropa und außerhalb Europas unter dem Handelsnamen Zithromax ermöglichte. Azithromycin findet Anwendung bei Infektionen der Atemwege einschließlich Lungenentzündungen, akuter Exazerbation der chronischen Bronchitis, Nasennebenhöhlenentzündungen, Entzündungen im Rachenbereich und Mandelentzündungen. Weiterhin wird Azithromycin bei akuten Mittelohrentzündungen, Haut- und Wundinfektionen, Lyme-Borreliose, bakterieller Konjunktivitis, bei Urethritis durch Chlamydien und zur Prophylaxe sogenannter MAK-Infektion (Mycobacterium-avium-intrazellulare-Komplex-Infektion) bei immungeschwächten Patienten verwendet.

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    Azithromycin dihydrate is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium. Azithromycin 250 mg Capsules. 2. Qualitative and quantitative composition. Each capsule contains azithromycin dihydrate equivalent to 250 mg of azithromycin. Azithromycin, as the dihydrate, is a white crystalline powder with a molecular formula of C 38 H 72 N 2 O 12 •2H 2 O and a molecular weight of 785.0. ZITHROMAX tablets contain azithromycin dihydrate equivalent to 600 mg azithromycin.

    Bactericidal and bacteriostatic; inhibits protein synthesis after binding with 50S ribosomal subunit of susceptible organisms. Demonstrates cross-resistance to erythromycin-resistant gram-positive strains and resistance to most strains of Enterococcus faecalis and methicillin-resistant Staphylococcus aureus. pneumoniae Adults: Instill 1 drop in affected eye(s) b.i.d., 8 to 12 hours apart for first 2 days; then instill 1 drop in affected eye(s) once daily for next 5 days Mild community-acquired pneumonia Adults: 500 mg P. Oral suspension: 100 mg/5 ml in 15-ml bottles; 200 mg/5 ml in 15-ml, 22.5-ml, and 30-ml bottles Oral suspension (Zmax extended-release): 2-g bottle Powder for injection: 500 mg in 10-ml vials Powder for oral suspension: 100 mg/5 ml, 200 mg/5 ml, 1,000 mg/packet Solution (ophthalmic): 1% in 5-ml bottle filled with 2.5 ml solution Tablets: 250 mg, 500 mg, 600 mg Tablets (Tri-Pak): three 500-mg tablets Tablets (Z-Pak): six 250-mg tablets Bacterial conjunctivitis caused by CDC coryneform group G, H. aureus Adults and adolescents ages 16 and older: 500 mg I. (no more than 500 mg/dose) on day 1, then 5 mg/kg (no more than 250 mg/dose) for 4 more days Community-acquired pneumonia caused by Chlamydia pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Streptococcus pneumoniae, Legionella pneumophila, Moraxella catarrhalis, and S. daily for a total of 7 to 10 days Children ages 6 months to 16 years: 10 mg/kg P. on days 2 through 5 Pharyngitis and tonsillitis Adults: 500 mg P. on day 1, then 250 mg/day for next 4 days, to a total dosage of 1.5 g Children ages 2 and older: 12 mg/kg P. Azithromycin should not be used in patients with pneumonia who are judged to be inappropriate for oral therapy because of moderate to severe illness or risk factors. (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZITHROMAX (azithromycin) and other antibacterial drugs, ZITHROMAX (azithromycin) should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. (1.4) ZITHROMAX (azithromycin) is a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Recommended dosages and durations of therapy in adult and pediatric patient populations vary in these indications. To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZITHROMAX (azithromycin) and other antibacterial drugs, ZITHROMAX (azithromycin) should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. After mixing, store suspension at 5° to 30°C (41° to 86°F) and use within 10 days. ZITHROMAX 250 mg tablets are supplied as pink modified capsular shaped, engraved, film-coated tablets containing azithromycin dihydrate equivalent to 250 mg of azithromycin.

    Azithromycin dihydrate

    Zitromax Azithromycin Dihydrate - 500mg 3 TabletsTurkey - United., Azithromycin 250 mg Capsules - Summary of Product. - eMC

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  3. Azithromycin-Dihydrat. siehe unter Azithromycin. Unterstützen Sie das PharmaWiki mit einer Spende! © PharmaWiki 2007-2019 - PharmaWiki informiert.

    • PharmaWiki - Azithromycin-Dihydrat.
    • Zithromax Azithromycin Side Effects, Interactions, Warning, Dosage..
    • Azithromycin dihydrate - DrugBank.

    Generic Name AZITHROMYCIN DIHYDRATE. Each film-coated tablet 250 mg and 500 mg contains azithromycin dihydrate equivalent to azithromycin 250 mg and 500 mg, respectively. Each 5 mL of powder for oral suspension, when reconstituted as directed, contains azithromycin dihydrate equivalent to azithromycin 200 mg. ZITHROMAX 250 mg tablets are supplied as pink modified capsular shaped, engraved, film-coated tablets containing azithromycin dihydrate equivalent to 250. Azithromycin dihydrate ≥98% HPLC; CAS Number 117772-70-0; Synonym N- Methyl-11-aza-10-deoxo-10-dihydroerythromycin A, CP-62993; Linear.

     
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