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Learn about Retin-A, what it is, how it works, and how to use it correctly at EverydayHealth.com, the leading online source of health news and. However, though tretinoin can be very helpful for some individuals, using Retin-A without a prescription can also cause a number of adverse side effects. Retin-A Side Effects. The problem with using Retin-A without a prescription is that these creams have a number of problems that are experienced by most users in the first stages. Dec 20, 2017. I've used Retin-A for years and I immediately noticed a change in my skin. Learn how it works, why it is a miracle cream and how to pay less for. The most famous retinol product is Retin-A, which was approved by the FDA in 1971 as a prescription treatment for acne. While there’s no such thing as a miracle, retinols come close. But while user’s pimples were vanishing, they started seeing other benefits to their skin. 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