The main evidence supporting the CDC's statement was a retrospective cohort study consisting of a record review and dental examination of 271 children living on a Native American reservation. No staining was detected in any of the 58 children who had been treated with doxycycline before the age of 8 years or in any of the 213 children who had not been exposed to the drug. Enamel hypoplasia was present in 4% of children in both cohorts.2Lyme disease, unlike Rocky Mountain spotted fever, is seldom fatal and can be treated with antibiotics other than doxycycline. A single dose of doxycycline is recommended for prophylaxis after a tick bite. Given the CDC's statement about its safety, it would seem reasonable to use doxycycline for prophylaxis in all age groups. Wiebe, Pharm D, FSVHP, DICVP, is the director of pharmacy and an adjunct associate professor in the department of medicine and epidemiology at University of California, Davis, Veterinary Medical Teaching Hospital. She is also an adjunct clinical professor in the department of pharmacy at University of California, San Francisco, where she earned her doctorate in clinical pharmacy. She completed a postdoctoral fellowship in the department of medical oncology at Yale University. She has given numerous lectures on antibiotic stewardship and authored Minocycline and doxycycline are semisynthetic antibiotics in the tetracycline family. Both are bacteriostatic; prevent bacterial growth by interfering with protein synthesis; and have antibacterial, anti-inflammatory, neuroprotective, cytoprotective,) may be more susceptible to CNS side effects caused by minocycline than by doxycycline, as both drugs are transported by P-glycoprotein and minocycline is more lipophilic than doxycycline; however, this has not been observed clinically. so doxycycline may be preferred in dogs with ophthalmic infections. 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