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    PARIS, Feb 23 (APM) - Pfizer has announced it will stop marketing ulcer drug Cytotec (misoprostol) in France because of widespread misuse of the product in gynaecology, Le Parisien reported on Monday (p17). French authorities had been aware of the situation and had already warned healthcare professionals against the use of Cytotec outside of its authorised indications, notably because of the risk of overdose. French drug watchdog ANSM told Le Parisien a product from Danish company Azanta, Angusta, with the same active ingredient as Cytotec, has received a marketing authorisation, but will not be available for some time. Despite 32 manufacturing sites and 8,500 jobs in the field, representing 19% of the pharmaceutical manufacturing sector in terms of headcount, “France mostly produces vaccines and recombinant proteins,” the article noted. Friday’s Libération (p9) reports on the “Novartisgate” scandal in Greece, saying that the parliament has decided to create an investigation committee to clarify bribery accusations targeting 4,200 physicians, 10 ministers and civil servants. Thursday’s Le Parisien (brief p9) as well as Wednesday’s Le Figaro (p12) reported that the French authorities have suspended treatment initiation with Gedeon Richter’s uterine fibroid drug Esmya (ulipristal acetate), after the EMA announced that 51 women have suffered from severe liver injuries after treatment (APMHE 55866, APMHE 55898). Monday’s Le Parisien (p9) and Le Figaro (website) announced that a new alternative to Merck KGa A’s Levothyrox, Tcaps from Laboratoires Genevrier, will be available to patients early April. Cytotec is indicated for the healing of duodenal ulcer and gastric ulcer including those induced by nonsteroidal anti-inflammatory drugs (NSAID) in arthritic patients at risk, whilst continuing their NSAID therapy. In addition, Cytotec can be used for the prophylaxis of NSAID-induced ulcers. Adults Healing of duodenal ulcer, gastric ulcer and NSAID-induced peptic ulcer: 800 micrograms daily in two or four divided doses taken with breakfast and / or each main meal and at bedtime. Treatment should be given initially for at least 4 weeks even if symptomatic relief has been achieved sooner. In most patients ulcers will be healed in 4 weeks but treatment may be continued for up to 8 weeks if required. If the ulcer relapses further treatment courses may be given. Prophylaxis of NSAID-induced peptic ulcer: 200 micrograms twice daily, three times daily or four times daily. Dosage should be individualised according to the clinical condition of each patient.

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