In a population-based cohort study of patients aged 65 and older, researchers found that those taking selective serotonin reuptake inhibitors (SSRIs) — the class of antidepressants that includes popular drugs like Prozac, Celexa and Zoloft — were more likely to suffer adverse effects than people not taking the medications. Those on SSRIs were more likely to die, have a stroke, suffer falls, fracture bones and have seizures. The study also found significantly more adverse outcomes associated with SSRIs than with an older class of medications known as tricyclic antidepressants. PHOTOS: Portraits of Centenarians However, the relative benefits of these drugs — a factor that was not captured by the study — need to be considered along with the risks when deciding which medication to prescribe for older patients, the authors said. There is still much that is unknown about the adverse effects of antidepressants in this age group because seniors tend to be underrepresented in clinical trials of the drugs, and most trials are short-term. Elderly patients with depression also tend to have co-existing medical conditions and many take other drugs; they may also be more sensitive to drug side effects than younger patients. In the current study, researchers led by Carol Coupland, an associate professor of medical statistics at the University of Nottingham, looked at prescription data on 60,746 patients aged 65 to 100 years who were newly diagnosed with depression between 19. Sertraline is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD). Sertraline belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the activity of a chemical called serotonin in the brain. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Sertraline pregnancy risk Metformin risks Depression is the most common mental health problem in the elderly1 and is. the best safety profile in the elderly are citalopram, escitalopram, and sertraline. Increased side effects from antidepressant use in the elderly are thought to be. Find a comprehensive guide to possible side effects including common and rare side effects when taking Zoloft Sertraline Hcl for healthcare professionals and. Aug 8, 2011. Elderly patients with depression also tend to have co-existing. they may also be more sensitive to drug side effects than younger patients. Commonly reported side effects of sertraline include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia. Other side effects include: abdominal pain, agitation, pain, vomiting, anxiety, hypouricemia, and malaise. See below for a comprehensive list of adverse effects. Applies to sertraline: oral solution, oral tablet Along with its needed effects, sertraline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking sertraline: Some side effects of sertraline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. Questions about personal health should always be referred to a physician or other health care professional. 2, 2011 (Health Day News) -- New research suggests that hugely popular antidepressants such as Prozac and Effexor might not always be the best choice for seniors, since they seem to have more side effects than older antidepressants do. Prozac (fluoxetine) and Effexor (venlafaxine) belong to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs), and are generally considered safe and effective. 2 issue of the BMJ finds that an older group of drugs known as tricyclic antidepressants may sometimes be safer in people over the age of 65. Still, several factors need to be considered when choosing an antidepressant, possible side effects being just one of them."The choice of class of antidepressant is a complex decision, and some evidence is still lacking to help with that choice in older patients," said study author Carol Coupland, associate professor of medical statistics at the University of Nottingham. "Low-dose [tricyclic antidepressants] may be more suitable in frail elderly patients at increased risk of falls and fracture."Although SSRIs (which also include Celexa, Paxil and Zoloft) are widely prescribed for depression in seniors, few trials have actually looked at the safety and effectiveness of these drugs in this group of people, added Angie Hochhalter, an assistant professor of internal medicine at Texas A&M Health Science Center College of Medicine."We don't find out how the drugs actually work [for seniors] until they've been out for a while," noted Hochhalter, who is also a research scientist in geriatrics at Scott & White in Temple. In the study, Coupland's team looked at prescription data on more than 60,000 patients aged 65 to 100 who had been newly diagnosed with depression. Ninety percent of patients had received one or more prescriptions for antidepressants, 55 percent of those for an SSRI and 32 percent for a tricyclic antidepressant. Seniors on SSRIs had a higher risk of dying, having a stroke, falling, breaking a bone and seizures compared with those not taking any antidepressant. Over the course of a year, 10.6 percent of seniors taking an SSRI died vs. Zoloft side effects in elderly Zoloft sertraline dosing, indications, interactions, adverse effects, and., Common Side Effects of Zoloft Sertraline Hcl Drug Center - RxList Tamoxifen or aromatase inhibitorsCialis reviews from users Q What are the effects of sertraline in elderly people with depression, taking. On the other hand, considering that many reported side effects of sertraline are. Sertraline improves depression scores in the elderly in the short term.. Newer Antidepressants May Not Be as Safe for Seniors. Side Effects Of Zoloft In The Elderly -. Elderly patients, patients taking. These are not all the possible side effects of ZOLOFT. For more information, ask your healthcare provider or pharmacist. Find patient medical information for Zoloft Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Sertraline is used to treat depression, obsessive-compulsive disorder OCD, panic. However, elderly patients may be more sensitive to the effects of this.